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Effects of α-dendrotoxin and dendrotoxin K on extracellular excitatory amino acids and on electroencephalograph spectral power in the hippocampus of anaesthetised rats

✍ Scribed by D.A Richards; L.A Morrone; G Bagetta; N.G Bowery


Book ID
117471181
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
158 KB
Volume
293
Category
Article
ISSN
0304-3940

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Alpha-dendrotoxin (a-DTx), a snake venom toxin which blocks several types of fast-activating voltagedependent potassium channels, induces limbic seizures and neuronal damage when injected into the brain. The mechanisms underlying these convulsant and neuropathological actions are not fully understoo