Effects of vinyl chloride on liver function of exposed workers, evaluated by measurements of plasma clearance of the 99Tc–N-2,4-dimethylacetanilido-iminodiacetate complex
✍ Scribed by Michał Studniarek; Krzysztof Durski; Julian Liniecki; Dariusz Brykalski; Anna Poznańska; Maria Głuszcz
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 418 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0260-437X
No coin nor oath required. For personal study only.
✦ Synopsis
In 77 males exposed occupationally to vinyl chloride (VC), the plasma clearance (Ct) of y9mTc-N(2,4-dimethylacetani1ido)iminodiacetate ('HEPIDA' complex) was determined. The results were juxtaposed with a scaled assessment of liver parenchyma performance based upon clinical examination and a series of biochemical tests. Detection of the diagnosable damage of liver parenchyma by means of the reduced clearance was sensitive (90%) at the reasonable specificity of 74%. Probability of exclusion of liver damage in patients with the clearance above 240 ml min-I 1.73 m-' amounted to 92%.
There was a significant correlation between degree of exposure to VC and the frequency of low clearance values.
It appears that the periodic determination of the yymTc-HEPIDA clearance in workers exposed to VC allows the assessment of incipient liver damage and signals the need for prophylactic measures.