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Effects of ventromedial hypothalamic lesions on adipose tissue of weanling male rats

✍ Scribed by J. K. Goldman; L. L. Bernardis; R. G. MacKenzie; M. Kodis; R. Luboshitzky

Publisher
Springer
Year
1981
Tongue
English
Weight
504 KB
Volume
20
Category
Article
ISSN
0012-186X

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✦ Synopsis

In weanling male rats, destruction of the ventromedial hypothalamus causes increased carcass lipid deposition and decreased linear growth without changes in food intake or blood glucose levels. These changes are not dependent on altered pituitary function. Lipogenesis and glucose utilization are increased in vivo and in vitro, while gluconeogenesis is accelerated in vivo. The enhanced lipogenesis occurs before increased gluconeogenesis.

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Food intake of weanling rats with lesion
Food intake of weanling rats with lesions in the ventromedial and dorsomedial hypothalamic nuclei in response to intragastric loading and caloric density manipulation
✍ Dr. Lee L. Bernardis; John R. Border πŸ“‚ Article πŸ“… 1975 πŸ› John Wiley and Sons 🌐 English βš– 639 KB

## Abstract Male rats received bilateral electrolytic lesions shortly after weaning in the ventromedial (VMN) and dorsomedial (DMN) hypothalamic nuclei, respectively. A third group of rats served as sham‐operated controls. The animals were subjected to intragastric preloading with 33% d‐glucose and