Effects of varying doses of spironolactone without and with nitrates on portal vein pressure and kidney function in partial portal vein ligated rats

✍ Scribed by M Van de Castelle; G Van Roey; F Nevens; J Fevery

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 248 KB
• Volume: 24
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.510240632

✦ Synopsis

On day 0, the day before the first gavage, and on patients. This has stimulated the search for alternative drugs day 7 of treatment, blood and 24-hour urine sampling were perin the treatment of portal hypertension. Recent data have formed to determine (Na / ), (K / ), (creatinine), and osmolality. Hence shown that spironolactone lowers portal pressure even in pacreatinine clearance, free water clearance, fractional Na / excretion tients without ascites. [5] Spironolactone is assumed to lower (FE), and urinary (Na / )/(K / ) ratio were calculated. Creatinine clear- portal pressure by reducing the enhanced circulating plasma ance was calculated as: (creatinine) urine 1 diuresis/(creatinine) se- rum and expressed as mL/min. Free water clearance was calculated as diuresis minus osmolar clearance and the FE of sodium as urinary Na / clearance divided by creatinine clearance or (Na / ) serum 1 (cre-Abbreviations: HVPG, hepatic venous pressure gradient; IsMn, isosorbide-5-mononi-atinine) urine/(Na / ) urine 1 (creatinine) serum and expressed as trate; FE, fractional Na / excretion. percentage. FE of Na / was used as a parameter of natriuresis in From the