Effects of various oxygenated sterols on cellular sterol biosynthesis in chinese hamster lung cells resistant to 25-hydroxycholesterol

The effect of hypoxia on acquired drug r

The effect of hypoxia on acquired drug resistance and response to epidermal growth factor in chinese hamster lung fibroblasts and human breast-cancer cells in vitro

✍ R. Kalra; A-M. Jones; J. Kirk; G. E. Adams; I. J. Stratford 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 646 KB

## Abstract Prolonged hypoxia induced transient drug resistance in Chinese hamster lung fibroblasts. Previously hypoxic cells were resistant to adriamycin and resistant to etoposide. Complete recovery of etoposide sensitivity was observed following re‐aeration for 24 hr. A change in P‐glycoprotein