This simple study leads to manifold consequences which may be advantageously utilized by the formulator and researcher. Control of solubility as a function of dielectric constant variation might have many applications such as increasing the solubility of drugs by using additives such as sucrose or other sugars. On the other hand, decreased solubility may also be useful in a kinetic sense. Since a drug, such as aspirin suspension, will only degrade depending upon the amount of drug in solution, decreased solubility could lead to increased stability to some degree. This approach could be quite useful for aspirin, sulfonamides. antibiotics, and other common pharmaceutical suspensions.
Preliminary work indicates that m e t h o d and other viscosity-inducing agents in solution have dielectric constants higher than that of pure water.
These vehicles also possess the proper consistency for physical suspension, stability, and palatability. Increased chemical stability v i a decreased solubility or increased polarity (dielectric constant) is a definite possibility. Studies along these lines are being conducted in these laboratories and results will be reported in future communications.
REFERENCES
(1) Maryott. A. A.. and Malmberg. C. G., J . Rcs. Noll. Bur. Std. 45 290(1950).
(2) Ak'erld G .