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Effects of variable sampling on COMFA coefficient contour maps

✍ Scribed by G. Greco; E. Novellino; M. Pellecchia; C. Silipo; A. Vittoria


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
274 KB
Volume
12
Category
Article
ISSN
0263-7855

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πŸ“œ SIMILAR VOLUMES


Effects of variable selection on CoMFA c
✍ Giovanni Greco; Ettore Novellino; Maurizio Pellecchia; Carlo Silipo; Antonio Vit πŸ“‚ Article πŸ“… 1994 πŸ› Springer Netherlands 🌐 English βš– 973 KB

An example of a CoMFA study is described with the aim to discuss one of the major problems of this 3D QSAR method: lack of variable selection. It is shown that the use of nonrelevant energy parameters might produce CoMFA contour maps which poorly reflect the actual nature of the binding site and are

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✍ Nicola J. Camp; Aruna Bansal πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 33 KB πŸ‘ 2 views

Sib pairs were selectively sampled for extreme concordance or discordance for the quantitative trait Q1, a simulated phenotype (GAW10). Two selective sampling criteria were used (SC1 and SC2), and results for these were compared to linkage analyses using all pairs (ALL). In total 773 sib pairs were