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Effects of Up to 5 Years of Denosumab Treatment on Bone Histology and Histomorphometry: The FREEDOM Study Extension

✍ Scribed by Brown, Jacques P; Reid, Ian R; Wagman, Rachel B; Kendler, David; Miller, Paul D; Jensen, Jens-Erik Beck; Bolognese, Michael A; Daizadeh, Nadia; Valter, Ivo; Zerbini, Cristiano AF; Dempster, David W

Book ID
121672186
Publisher
American Society for Bone and Mineral Research
Year
2014
Tongue
English
Weight
263 KB
Volume
29
Category
Article
ISSN
0884-0431

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## Abstract Denosumab, a human monoclonal antibody against RANKL, reversibly inhibits osteoclast‐mediated bone resorption and has been developed for use in osteoporosis. Its effects on bone histomorphometry have not been described previously. Iliac crest bone biopsies were collected at 24 and/or 36