This study assessed the effect of unilateral strength training at 80% one repetition maximum and of detraining on bone mineral density (BMD, g/cm-2) and bone mineral content (sigma BMC, g) in young women. Twelve female physiotherapy students trained their left limb by leg press an average of four times per week for 1 year followed by 3 months of detraining. Twelve students served as controls. Repeated bone measurements were performed by dual energy X-ray absorptiometry of the lumbar spine, femoral neck, distal femur, patella, proximal tibia, and calcaneus. The training increased the muscle strength of the trained limb, and the BMD of the same limb showed a nonsignificant but systematic increase in distal femur, patella, and proximal tibia, and in sigma BMC of the five measured limb sites (considered an index of the total osteogenic effectiveness of the training). Simultaneously, the muscle strength increased in the untrained limb as an evidence of cross-training effect. A corresponding small but systematic increase was also seen in BMD of this limb as well as in sigma BMC. After the cessation of training, leg extension strength was retained but BMD and sigma BMC of the trained and untrained limbs declined towards baseline values in 3 months. The BMD and sigma BMC values in the control group showed an increasing tendency during the follow-up but the changes were less than 1%. The differences of the changes in BMD and sigma BMC between the left and right limb in the control group, as well as between the same limb in the training and control groups were nonsignificant.(ABSTRACT TRUNCATED AT 250 WORDS)