Effects of Type 1A Serotonin Receptor Agonist 8-OH-DPAT on Immune Response
โ Scribed by G.V. Idova; M.A. Cheido; E.N. Zhukova; E.L. Al'perina; L.V. Devoino
- Book ID
- 110322993
- Publisher
- Springer US
- Year
- 2001
- Tongue
- English
- Weight
- 382 KB
- Volume
- 132
- Category
- Article
- ISSN
- 0007-4888
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๐ SIMILAR VOLUMES
## Abstract The title compounds were synthesised in 7 steps from 1,7โdihydroxynaphthalene as follows: 1,7โdihydroxynaphthalene was methylated and subjected to a Birch reduction to yield 8โmethoxyโ2โtetralone. Reductive amination with sodium cyanoboro[^3^H]hydride and nโpropylamine gave 8โmethoxyโ2โ
The present study investigated alterations of the regulation of serotonin (5-hydroxytryptamine; 5-HT) release by 5-HT 1A autoreceptors following single and repeated treatment with the 5-HT 1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Rats were pretreated with 8-OH-DPAT (1.