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Effects of two representative antitumor ruthenium(III) complexes on thermal denaturation profiles of DNA

✍ Scribed by L. Messori; A. Casini; D. Vullo; S.G. Haroutiunian; E.B. Dalian; P. Orioli

Book ID: 108331914
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 118 KB
Volume: 303
Category: Article
ISSN: 0020-1693
DOI: 10.1016/s0020-1693(99)00528-9

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Thermal denaturation of direct-mixed and reconstituted polylysine-DNA complexes in 2.5 X 10-4 M EDTA, pH 8.0 and various concentrations of NaCl has been studied. For both complexes, increasing ionic strength of the solution raises T,, the melting temperature of free base pairs. The linear dependence