Effects of wild-type p53 expression on t
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Daniel Hochhauser; Nikola I. Valkov; Jana L. Gump; Irene Wei; Carolyn O'Hare; Jo
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Article
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1999
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John Wiley and Sons
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English
⚖ 455 KB
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The p53 null HL-60 cell line was transfected with plasmids coding for either the wild-type p53 or mutant p53 gene. The stable expression of wild-type p53 resulted in a significant increase in sensitivity to the topoisomerase II poisons etoposide and doxorubicin, but not to the topoisomerase II inhib