Effects of transient regional ischemia on left ventricular diastolic function

✍ Scribed by Donald A. Conetta; Leonard G. Christie; Robert L. Feldman; Wilmer W. Nichols; Carl J. Pepine; C. Richard Conti

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 594 KB
• Volume: 8
• Category: Article
• ISSN: 0091-2751
• DOI: 10.1002/jcu.1870080309

✦ Synopsis

Abstract

Simultaneous left ventricular echograms and high‐gain pressure recordings were made during 30 s of regional myocardial ischemia induced by snare occlusions of the proximal left anterior descending (LAD) or left circumflex (LCx) coronary arteries in open‐chest dogs. Left ventricular diastolic diameter (d) and pressure (p) were measured during slow filling. A normalized (for diameter D) distensibility estimate (DE = Δ__d__/Δ__p/D__) was calculated, as were slow filling slopes (SFSs) of the septum and posterior wall. After occlusion, significant (p < 0.05) decreases of DE and anterior and posterior left‐ventricular‐wall mid‐diastolic normalized slow‐filling slopes (ASFS/D and PSFS/D) were observed. Correlations were noted between percentage decreases of DE and ASFS/D (r = 0.69, p < 0.0001) and PSFS/D (r = 0.62, p < 0.0001). No significant differences between decreases of DE and SFS were noted between ischemic and non‐ischemic regions. Transient regional myocardial ischemia was associated with a generalized alteration in left ventricular filling patterns in mid‐diastole.