Effects of Transforming Growth Factor- β on Collagen Synthesis by Fetal Rat Lung Epithelial Cells
✍ Scribed by DiMari, Samuel J.; Howe, Anita M.; Haralson, Michael A.
- Book ID
- 115491663
- Publisher
- American Thoracic Society
- Year
- 1991
- Tongue
- English
- Weight
- 985 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1044-1549
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## Abstract Insulin‐like growth factor binding protein‐3 (IGFBP‐3) has been proposed to mediate the growth inhibitory effects of transforming growth factor (TGF)‐β in breast and prostate cancer cells. Both TGF‐β and exogenous IGFBP‐3 inhibit DNA synthesis in Mv1 mink lung epithelial cells (CCL64).
We have previously shown that transforming growth factor-b1 (TGF-b1) enhances the epidermal growth factor-(EGF) and transforming growth factor-a (TGF-a)stimulated motility of rat hepatocytes in an extracellular matrix (ECM)-dependent fashion (Stolz and Michalopoulos, 1997, J. Cell. Physiol., 170:57-