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Effects of trans-2,4-dimethoxystibene against the neurotoxicity induced by Aβ25–35 both in vitro and in vivo

✍ Scribed by Can-Jun Ruan; Li Zhang; Di-Hua Chen; Zhan Li; Guan-Hua Du; Lan Sun

Book ID: 116777228
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 1006 KB
Volume: 67
Category: Article
ISSN: 0168-0102
DOI: 10.1016/j.neures.2010.03.009

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## Abstract Studies with in‐vitro‐cultured neurons treated with amyloid‐β (Aβ) peptides demonstrated neuronal loss by apoptosis that is due, at least in part, to the perturbation of intracellular Ca^2+^ homeostasis. In addition, it was shown that an endoplasmic reticulum (ER)‐specific apoptotic pat