Effects of thyroid hormone on bone
β Scribed by Nikolaos Stathatos; Leonard Wartofsky
- Book ID
- 111635443
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 214 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1534-8644
No coin nor oath required. For personal study only.
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To study the mechanism of action of thyroid hormones on bone, we examined the effects of immunosuppressive and nonimmunosuppressive cyclosporins, as well as of transforming growth factor beta 1 (TGF beta 1), 17 beta-estradiol (E2), and dihydroxytestosterone (DHT) on thyroxine (T4)- and triiodothyron
## Abstract Excess thyroid hormone (TH) in adults causes osteoporosis and increases fracture risk. However, the mechanisms by which TH affects bone turnover are not elucidated. In particular, the roles of thyroid hormone receptor (TR) isotypes in the mediation of TH effects on osteoblastβmediated b