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Effects of therapeutic radiation on the development of multiple primary tumors of the head and neck

โœ Scribed by Friedman, Michael ;Toriumi, Dean M. ;Strorigl, Terri ;Grybauskas, Vytenis T. ;Skolnik, Emanuel

Publisher
Wiley (John Wiley & Sons)
Year
1988
Weight
287 KB
Volume
10
Category
Article
ISSN
0148-6403

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โœฆ Synopsis

Previous studies on the carcinogenesis of radiotherapy for head and neck tumors have been conflicting. A series of 1,856 head and neck cancer patients was classified into three groups based on treatment: 1) surgery alone, 2) surgery with pre-or postoperative radiotherapy, or 3) radiotherapy alone. Patients who were followed-up for longer than 5 years were used to compare the incidence of multiple primaries among the three groups. The overall incidence of multiple primary head and neck malignancies in this study was 9%. There was no significant difference in the incidence of multiple primaries in the groups treated by surgery alone versus the combined surgery and radiotherapy group. In this study, radiotherapy appeared neither to protect against nor induce multiple primaries within head and neck radiation portals. HEAD & NECK SURGERY 1O:S48-551,1988

Acknowledgment: Special thanks to Sally Freels, Clinical Advisor, Northwestern University School of Medicine, for her assistance in performing the statistical analysis. Presented in part before the Triological Society, 89th annual meeting,

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