Spleen cells of BALB/c mice that had been inoculated with syngeneic plasmacytoma MOPC 104E were cultured for 11 days in T-cell growth factor (TCGF) and ultrasonicated tumor extract (USE). Cultured lymphocytes (MOPC-CL) possessed three-fold more lytic units than normal spleen cells cultured in TCGF w
Effects of the removal of adherent and phagocytic cells on the spleen cell lymphoproliferative response of tumor-bearing mice
β Scribed by Aileen M. Hyde; Robert B. Stagg; Robin McEachron; Robert L. Nutter
- Publisher
- Springer-Verlag
- Year
- 1985
- Tongue
- English
- Weight
- 651 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0340-7004
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## Abstract The behavior of spleen cells from tumorβbearing mice, visβΓ βvis isologous tumor cells, was investigated by means of an __in vivo__ adoptive neutralization test. C~3~H/eB mice were challenged with tumor cells from a chemically induced fibrosarcoma. Spleens from these animals were removed
Some T cell-dependent immune parameters were examined in mice bearing a large MOPC-315 plasmacytoma before and after treatment with a low dose (15 mg/kg) of CY. Prior to CY therapy, spleen cells from mice bearing a large MOPC-315 tumor were depressed in their ability to generate an in vitro cytotoxi