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Effects of the pyrrolizidine alkaloid senecionine and the alkenals trans-4-OH-hexenal and trans-2-hexenal on intracellular calcium compartmentation in isolated hepatocytes

โœ Scribed by Donna S. Griffin; H.J. Segall

Book ID
115781039
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
697 KB
Volume
38
Category
Article
ISSN
0006-2952

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Role of cellular calcium homeostasis in
Role of cellular calcium homeostasis in toxic liver injury induced by the pyrrolizidine alkaloid senecionine and the alkenaltrans-4-OH-2-hexenal
โœ Griffin, Donna S. ;Segall, H. J. ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 699 KB

The pyrrolizidine alkaloid senecionine has been shown to be hepatotoxic, genotoxic, and cytotoxic. However, the biochemical mechanism by which senecionine produces hepatocellular toxicity remains to be elucidated. The role of calcium homeostasis in toxic liver injury was examined in isolated rat hep