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Effects of the protein tyrosine kinase inhibitor, herbimycin A, on prolactin gene expression in GH3 and 235-1 pituitary tumor cells

✍ Scribed by William M Billis; Bruce A White

Book ID
117350848
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
947 KB
Volume
1358
Category
Article
ISSN
0167-4889

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## Abstract The effects of rottlerin, a known inhibitor of protein kinase C‐δ activation, on ion currents were investigated in pituitary tumor (GH~3~) cells. Rottlerin (0.3–100 Β΅M) increased the amplitude of Ca^2+^‐activated K^+^ current (I~K(Ca)~) in a concentration‐dependent manner with an EC~50~