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Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and Doppler measures in patients with pulmonary arterial hypertension

✍ Scribed by N. Galie; A.L. Hinderliter; A. Trobicki; T. Fourme


Book ID
114347630
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
35 KB
Volume
12
Category
Article
ISSN
1062-1458

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## Abstract ## Objective Increased endothelin activity may play a role in the pathogenesis of vascular injury, a primary feature of systemic sclerosis (SSc; scleroderma). Our goal was to test the hypothesis that treatment with the oral endothelin receptor antagonist bosentan might improve vascular