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Effects of the novel cyclosporine derivative PSC833 on glucose metabolism in rat primary cultures of neuronal and glial cells

✍ Scribed by Fatima Cruz; Armin Wolf

Book ID: 113992675
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 692 KB
Volume: 62
Category: Article
ISSN: 0006-2952
DOI: 10.1016/s0006-2952(01)00642-6

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## Abstract Palytoxin (PTX) is a potent marine phycotoxin that binds to the Na,K‐ATPase, converting this pump into an open channel. We have recently shown (Vale et al., 2006) that PTX causes an irreversible increase in the cytosolic calcium concentration ([Ca^2+^]~c~) in primary cultures of cerebel