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Effects of the monoamine oxidase A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic mice

✍ Scribed by Thomas Steckler; Gerhard Rammes; Magdalena Sauvage; Marcel M van Gaalen; Carla Weis; Walter Zieglgänsberger; Florian Holsboer

Book ID
114057498
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
940 KB
Volume
35
Category
Article
ISSN
0022-3956

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A reduction in glucocorticoid receptor (GR) function leads to hippocampus-dependent allocentric spatial learning deficits, altered novelty exploration and disrupted hippocampal long-term potentiation (LTP) in transgenic mice expressing a GR antisense construct. After continuous long-term treatment o