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Effects of the Intramolecular Disulfide Bond on Ligand Binding Dynamics in Myoglobin †

✍ Scribed by Uchida, Takeshi; Unno, Masashi; Ishimori, Koichiro; Morishima, Isao


Book ID
126960753
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
242 KB
Volume
36
Category
Article
ISSN
0006-2960

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Effect of ligand binding on the intramin
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## Abstract Effects of ligand binding on protein dynamics are studied via molecular dynamics (MD) simulations on two different enzymes, dihydrofolate reductase (DHFR) and triosephosphate isomerase (TIM), in their unliganded (free) and liganded states. Domain motions in MD trajectories are analyzed