Effects of the glutamate carboxypeptidase II (GCP2 1561C>T) and reduced folate carrier (RFC1 80G>A) allelic variants on folate and total homocysteine levels in kidney transplant patients
✍ Scribed by Winkelmayer, Wolfgang C.; Eberle, Corinna; Sunder-Plassmann, Gere; Födinger, Manuela
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 77 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0085-2538
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✦ Synopsis
Background:
The effect of the glutamate carboxypeptidase ii gcp2 1561c>t and the reduced folate carrier 1 rfc1 80g>a polymorphisms on folate and total homocysteine (thcy) plasma levels of kidney transplant patients are unknown.
Methods:
In a cross-sectional study of 730 kidney allograft recipients, gcp2 1561c>t, rfc1 80g>a, folate, and thcy plasma levels were analyzed using linear regression models that allowed dependent covariates to follow a gamma distribution for univariate and multivariate analyses.
Results:
The allele frequency for gcp2 1561c>t was 0.05, and 0.43 for rfc1 80g>a. heterozygosity or homozygosity for gcp2 1561c>t was associated with higher folate plasma levels compared to patients without mutation (p < 0.0001), while rfc1 80g>a showed no influence. multiple testing, also including mthfr 677c>t and mthfr 1298a>c, revealed no interaction between the different genotypes and the folate plasma concentration. neither gcp2 1561c>t nor rfc1 80g>a showed an association with thcy plasma levels.
Conclusion:
We conclude that gcp2 1561c>t is associated with elevated folate levels. gcp2 1561c>t and rfc1 80g>a are no major determinants of thcy plasma levels in kidney transplant patients.