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Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21Cip1 protein expression and cell cycle regulation in MCF-7 and MCF-10A cells

✍ Scribed by Yuan-Wan Sun; Christopher R. Herzog; Jacek Krzeminski; Shantu Amin; Gary Perdew; Karam El-Bayoumy


Book ID
113517571
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
857 KB
Volume
170
Category
Article
ISSN
0009-2797

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## Abstract The environmental pollutant 6‐nitrochrysene (6‐NC) is a potent mammary carcinogen in the rat. To determine if the results obtained in 6‐NC‐treated rodents can be applicable to humans, we examined its metabolic activation in primary cultures of human breast cells prepared from tissues ob