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Effects of the dihydropyridine Ca2+ channel antagonist nimodipine on kainic acid-induced limbic seizures

✍ Scribed by Richard P. Paczynski; Fredric B. Meyer; Robert E. Anderson


Book ID
108022772
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
729 KB
Volume
6
Category
Article
ISSN
0920-1211

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## Abstract Kainic acid (KA)‐induced status epilepticus (SE) is a well‐characterized model of excitotoxic neuronal injury. Excitotoxicity results from activation of specific glutamate receptors, with resultant elevation of intracellular Ca^2+^. The CA1 and CA3 subregions of the hippocampus are espe