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Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys

โœ Scribed by Nancy K. Mello; S. Stevens Negus; Kenner C. Rice; Jack H. Mendelson

Book ID
113841207
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
536 KB
Volume
85
Category
Article
ISSN
0091-3057

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An array of evidence indicates that long-term exposure to cocaine alters several components of the brain dopamine system. Because the release of dopamine in the nucleus accumbens (NAc) has been implicated in mediating the reinforcing effects of cocaine, changes in dopamine function can have profound