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Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats

✍ Scribed by Wolfgang Löscher; Dagmar Hönack


Book ID
115889031
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
836 KB
Volume
234
Category
Article
ISSN
0014-2999

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A competitive (NBQX) and a non-competitive (GYKI 52466) AMPA antagonist, and a competitive NMDA antagonist (D-CPPene) were tested against the development of kindling and against fully kindled seizures in amygdala-kindled rats. GYKI 52466, 10 mg/kg given i.p. 5 min prior to electrical stimulation in