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Effects of the combination of tumor-specific and nonspecific immunization on tumor suppression

✍ Scribed by Tsuneatsu Mori; Morimasa Sekiguchi; Genshichiro Fujii; Tsunamasa Inou; Masaru Kitamura

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
464 KB
Volume
9
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

The crushed whole Aoyama B cells attached to oil droplets were found to be most suitable for the adjuvant effect of Mycobacterium tuberculosis against tumor growth when judged by the criterion of effectiveness and a clinical application with minimal side effects. The immunogenicity of tumor cells was well stabilized and maintained with a suitable concentration of formalin; this was less than 1% and the optimum concentration was 0.05% or 0.1%. When the tumor cells treated with the optimum concentration of formalin were combined with suitable adjuvant, immunoprotection against the tumor progress was accelerated.

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