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Effects of the circadian rhythm of corticosteroids on leukocyte-endothelium interactions in the AM and PM

โœ Scribed by Steven D. House; Stacey Ruch; Walter F. Koscienski III; Christian W. Rocholl; Roberta L. Moldow

Book ID
117175017
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
950 KB
Volume
60
Category
Article
ISSN
0024-3205

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Monitoring of indices of haematological, renal and hepatic toxicity in rats after a single i.v. bolus of methotrexate has shown that they vary with the time of day at which the drug is administered. Maximum toxicity occurs after administration at 0600 h. Further experimentation has shown that the am