Effects of TGF-β1 on the proliferation and differentiation of human periodontal ligament cells and a human periodontal ligament stem/progenitor cell line
✍ Scribed by Shinsuke Fujii; Hidefumi Maeda; Atsushi Tomokiyo; Satoshi Monnouchi; Kiyomi Hori; Naohisa Wada; Akifumi Akamine
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 456 KB
- Volume
- 342
- Category
- Article
- ISSN
- 0302-766X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The lifespan of the tooth is influenced by the periodontal ligament (PDL), a specialized connective tissue that connects the cementum with the tooth socket bone. Generation of a cell line from PDL progenitor/stem cells would allow development of tissue engineering‐based regenerative PDL
Numerous studies have shown that hydrogen peroxide (H 2 O 2 ) inhibits proliferation and osteoblastic differentiation in bone-like cells. Human periodontal ligament fibroblasts (PLF) are capable of differentiating into osteoblasts and are exposed to oxidative stress during periodontal inflammation.
## Abstract Recent studies have shown that mesenchymal stem cells obtained from periodontal ligament (PDL‐MSCs) are multipotent cells that have similar features of the bone marrow and dental pulp MSCs and are capable of proliferating and producing different types of tissue such as bone and tooth as