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Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P-glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats

โœ Scribed by Young H. Choi; Jung H. Suh; Joo H. Lee; Il H. Cho; Myung G. Lee

Book ID
118111387
Publisher
Pharmaceutical Press
Year
2010
Tongue
English
Weight
204 KB
Volume
62
Category
Article
ISSN
2042-7158

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## Abstract Docetaxel is one of the most widely used anticancer drugs. A major problem with docetaxel treatment, however, is the considerable interpatient variability in docetaxel exposure. Another disadvantage of the drug is that it has a very low oral bioavailability and can, therefore, only be a