The effects of UVA, mixed UVA + B, and solar-simulated irradiation were examined in human keratinocytes and melanocytes cultured in vitro. Irradiation with UVA, UVA + B, or the solar simulator caused a dose-dependent decrease in keratinocyte cell numbers and thymidine incorporation at 24 hours, with
Effects of temperature on ultraviolet-induced erythema of human skin
β Scribed by Christopher R. Shea; John A. Parrish
- Publisher
- Springer-Verlag
- Year
- 1982
- Tongue
- English
- Weight
- 409 KB
- Volume
- 273-273
- Category
- Article
- ISSN
- 0340-3696
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β¦ Synopsis
Convective cooling of human skin to 20 ~ C or less for 1 h immediately after ultraviolet-B irradiation (UV-B, 290-320 nm) results in a significant increase in erythemal threshold when erythema was observed at 4-6h postirradiation. Cooling the skin immediately before UV-B irradiation showed no consistent influence on the erythema response. In neither case was an effect of cooling on erythemal threshold apparent when erythema was evaluated at 24 h postirradiation. These effects may be due to alterations in the diffusion kinetics of chemical mediators of inflammation, modification of vascular responsiveness, or reflect changes in temperature-dependent cellular repair or expression of UV-induced damage.
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