Effects of surface charges and cholesterol content on amino acid permeabilities of small unilamellar vesicles

Effects of Particle Size and Cholesterol

Effects of Particle Size and Cholesterol Content on the Partition Coefficients of Chlorpromazine and Triflupromazine between Phosphatidylcholine–Cholesterol Bilayers of Unilamellar Vesicles and Water Studied by Second-Derivative Spectrophotometry

✍ Shigehiko Takegami; Keisuke Kitamura; Tatsuya Kitade; Kazuhiro Hasegawa; Aya Nis 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 115 KB

Phosphatidylcholine (PC)-cholesterol (0 -30 mol%) unilamellar vesicles of several sizes (20 -600 nm) were prepared in buffer (pH 7.4) solutions by sonication or extrusion methods. The vesicle size was measured by a dynamic light-scattering method. Absorption spectra of chlorpromazine (CPZ) and trifl