Effects of suppressor mutations on nonallelic glucose 6-phosphate dehydrogenase mutants ofNeurospora crassa

✍ Scribed by W. A. Scott; Stuart Brody

• Book ID: 104784836
• Publisher: Springer
• Year: 1973
• Tongue: English
• Weight: 573 KB
• Volume: 10
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00485706

✦ Synopsis

Suppressor mutations have been isolated for bal and col-2, two slow-growing and nonaIlelic morphological mutants of Neurospora that carry defeetive G6PDs. Both suppressor mutations are located on linkage group I but are unlinked to the particular mutant that they suppress. The bal suppressor (su-B) increases the growth rate of bal and produces a more spreading morphology. su-B also decreases the G6P K m of G6PD in bal;su-B double mutants. The col-2 suppressor (su-C) has similar positive effects on the morphology of col-2 and influences the electrofocusing pattern of the col-2 G6PD. su-C is an unusual type of suppressor mutation in that, when present in a wild-type background, it affects the electrofocusing pattern and kinetic properties of the normal enzyme. The nature of the su-C mutation, plus the complex genetic control of the Neurospora G6PD, is discussed.