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Effects of sulindac on renal and extrarenal eicosanoid synthesis

✍ Scribed by Ciabattoni, Giovanni; Boss, Anders H; Patrignani, Paola; Catella, Francesca; Simonetti, Bianca M; Pierucci, Alessandro; Pugliese, Francesco; Filabozzi, Paola; Patrono, Carlo

Book ID: 109844251
Publisher: Nature Publishing Group
Year: 1987
Tongue: English
Weight: 342 KB
Volume: 41
Category: Article
ISSN: 0009-9236
DOI: 10.1038/clpt.1987.44

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The pharmacokinetics of low dose methotrexate (MTX) were evaluated in 12 rheumatoid arthritis patients in the presence and absence of steady-state levels of salicylic acid (ASA) and sulindac (SU). Using a Latin square design, patients were given MTX plus ASA (mean 3.4 g/day), MTX plus SU (mean 400 m