Effects of substance p on the spontaneous binding of salmonella minnesota r345 (rb) to human peripheral blood lymphocytes
✍ Scribed by Claudio De Simone; Aldo Misefari; Salvatore Antonaci; Angela B. Maffione; Emilio Jirillo; Vito Covelli
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 399 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0887-8013
No coin nor oath required. For personal study only.
✦ Synopsis
The effects of substance P (SP) on Salmonella minnesota R345 (Rb) binding to human peripheral blood lymphocytes (PBL) were evaluated. Two parameters of bacterial cytoadherence were considered, namely the binding lymphocytes (BL) and the number of bound-bacteriaAymphocyte (BB). The results showed that SP inhibits both BL and BB in a significant manner. Furthermore, distribution of Salmonella binding to CD4 + and CD8 + lymphocytes was studied following SP pretreatment of lymphoid cells. This neuropeptide is able to hamper the bacterial cytoadherence to both T-cell subpopulations and, in particular, the inhibitory effect on the T-suppressor/ cytotoxic subset was more pronounced.
These findings are discussed in terms of SP intervention in the mechanism of host protection against invading microorganisms.