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Effects of Subcutaneous Leptin Injections on Hypothalamic Gene Profiles in Lean and ob/ob Mice

✍ Scribed by Jiuhua Duan; Yang-Ho Choi; Diane Hartzell; Mary Anne Della-Fera; Mark Hamrick; Clifton A. Baile

Book ID: 109968777
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 236 KB
Volume: 15
Category: Article
ISSN: 1930-7381
DOI: 10.1038/oby.2007.314

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## Abstract Both central and peripheral leptin administrations reduce body weight, food intake, and adiposity in __ob/ob__ mice. In this study we compared effects of intracerebroventricular (ICV) and subcutaneous (SC) administration of leptin on bone metabolism in the appendicular and axial skeleto