Effects of subacute repeated injections of phencyclidine and MK-801 on substance P content in the rat brain
โ Scribed by H. Mitsushio; Y. Shirayama; T. Nishikawa; K. Takahashi
- Book ID
- 119117683
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 53 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0167-0115
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๐ SIMILAR VOLUMES
We investigated the effects of a schizophrenomimetic drug, phencyclidine (PCP), on substance P (SP) contents in the discrete rat brain areas using an enzyme-immunoassay for SP. The acute intraperitoneal (i.p.) administration of PCP (10 mg/kg), which is a noncompetitive antagonist of the N-methyl-D-a
The mRNA expression pattern for four different immediate early genes was examined dynamically in rat brain after administration of phencyclidine (PCP; 0.86 or 8.6 mg/kg) or MK801 (0.1 or 1.0 mg/kg). Following each treatment, the expression of cfos, cjun, junB, and zif268 mRNA changed distinctively a