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Effects of subacute pyridostigmine administration on mammalian skeletal muscle function

โœ Scribed by Michael Adler; Sharad S. Deshpande; Robert E. Foster; Donald M. Maxwell; Edson X. Albuquerque

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
799 KB
Volume
12
Category
Article
ISSN
0260-437X

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โœฆ Synopsis

The subacute effects of pyridostigmine bromide were investigated on the contractile properties of rat extensor digitorum longus (EDL) and diaphragm muscles. The chdinesterase inhibitor was delivered via subcutaneously implanted osmotic minipumps (Alzete) at 9 pg h-' (low dose) or 60 pg h-' (high dose). Animals receiving high-dose pyridostigmine pumps exhibited marked alterations in muscle properties within the first day of exposure that persisted for the remaining 13 days. With 0.1 Hz stimulation, EDL twitch tensions of treated animals were elevated relative to control. Repetitive stimulation at frequencies > 1 Hz led a use-dependent depression in the amplitude of successive twitches during the train. Recovery from pyridostigmine was essentially complete by 1 day of withdrawal. Rats implanted with low-dose pyridostigmine pumps showed little or no alteration of in vivo twitch tensions during the entire 14 days of treatment.

Diaphragm and EDL muscles excised from pyridostigmine-treated rats and tested in vitro showed no significant alterations in twitch and tetanic tensions and displayed the same sensitivity as muscles of control animals to subsequent pyridostigmine exposures. In the presence of atropine, subacutely administered pyridostigmine protected rats from two L D ~~ doses of the irreversible cholinesterase inhibitor, soman. In the absence of atropine, the L D ~O of soman was not altered by subacute pyridostigmine treatment.

* The opinions and assertions expressed herein are the private views of the authors and are not to be construed as official views of the Department of the Army or the Department of Defense. The experiments reported here were conducted according to the 'Guide

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