Effects of stimulus frequency and age on bidirectional synaptic plasticity in the dentate gyrus of freely moving rats
β Scribed by J.Harry Blaise; Joseph D Bronzino
- Book ID
- 117100947
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 228 KB
- Volume
- 182
- Category
- Article
- ISSN
- 0014-4886
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## Abstract We examined synaptic plasticity in the dentate gyrus (DG) of the hippocampus in vitro in juvenile C57Bl6 mice (28β40 days of age), housed in control conditions with minimal enrichment (Controls) or with access to an exercise wheel (Runners). LTP expression was significantly greater in s
Long-term potentiation (LTP) or long-term depression (LTD) can be produced in the dentate gyrus (DG) of the hippocampus with high-or low-frequency stimulation trains, respectively. Although LTP can be elicited in a variety of preparations, we know of no reports of LTD unaccompanied by seizure activi