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Effects of soman on calcium uptake in microsomes and mitochondria from rabbit aorta

✍ Scribed by Chao-Yu Hu; Chia-Hsuh Hsu; Casey P. Robinson

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
349 KB
Volume
11
Category
Article
ISSN
0260-437X

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✦ Synopsis

Daily administration of soman for several days results in several alterations in the vascular neuroeffector system. To determine whether or not soman alters intracellular Ca" uptake, the effects of acute exposure to soman or 7-day administration of 5pg kg-' of soman on the capacity of microsomes and mitochondria from rabbit aortic vascular smooth muscle to take up 45Ca2+ were determined. Acute exposure to soman concentrations of 1-100 p M did not alter significantly (-0.05) j5Caz+ uptake by either microsomes or mitochondria. On the other hand, 7-day soman administration markedly reduced (PC0.05) ''Ca*+ uptake by both microsomes and mitochondria. Thus, calcium uptake and intracellular calcium uptake-dependent responses will be affected by repeated soman administration.

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