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Effects of Sirt1 on DNA methylation and expression of genes affected by dietary restriction

✍ Scribed by Ions, Laura J; Wakeling, Luisa A; Bosomworth, Helen J; Hardyman, Joy EJ; Escolme, Suzanne M; Swan, Daniel C; Valentine, Ruth A; Mathers, John C; Ford, Dianne

Book ID: 118249133
Publisher: Springer Netherlands
Year: 2012
Tongue: English
Weight: 687 KB
Volume: 35
Category: Article
ISSN: 0161-9152
DOI: 10.1007/s11357-012-9485-8

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## Abstract Despite thousands of articles about 5‐methylcytosine (m^5^C) residues in vertebrate DNA, there is still controversy concerning the role of genomic m^5^C in normal vertebrate development. Inverse correlations between expression and methylation are seen for many gene regulatory regions [H