Effects of silymarin and formulation on the oral bioavailability of paclitaxel in rats
β Scribed by Joon Hee Park; Jung Hyun Park; Hye Jung Hur; Jong Soo Woo; Hwa Jeong Lee
- Book ID
- 113592566
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 346 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0928-0987
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Paclitaxel is a substrate of the efflux transporters such as Pβglycoprotein, and is mainly metabolized by the liver. Schisandrol B (Sch B), one of the active components in Schisandra, has been reported to be able to inhibit the activity of Pβgp and CYP3A. It might be possible that Sch B
A new, supersaturable self-emulsifying drug delivery system (S-SEDDS) of paclitaxel was developed employing hydroxypropyl methylcellulose (HPMC) as a precipitation inhibitor with a conventional SEDDS formulation. In vitro dilution of the S-SEDDS formulation results in formation of a microemulsion, f
The aim of this study was to evaluate the effect of curcumin (CUR) in oral bioavailability and therapeutic efficacy of paclitaxel (PTX) administered in nanoemulsion to SKOV3 tumor-bearing nu/nu mice. Oral administration of the mice with CUR at 50 mg/kg for 3 consecutive days resulted in a down regul
Fexofenadine has been identified as a substrate for both the efflux transporter, P-glycoprotein (P-gp), as well as the influx transporter, organic anion transporting polypeptide (OATP). Clinical studies in humans showed that fruit juices reduced the oral bioavailability of fexofenadine by preferenti