Effects of short-term occupational exposure to lead on erythrocyte glucose-6-phosphate dehydrogenase activity and serum cholesterol
✍ Scribed by Pierluigi Cocco; Stefano Salis; Maristella Anni; Maria E. Cocco; Costantino Flore; Antonio Ibba
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 429 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0260-437X
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✦ Synopsis
The effect of short-term occupational exposure to lead on erythrocyte glucosed-phosphate dehydrogenase (G6PD) activity and serum cholesterol was studied in 40 male workers of a lead and zinc foundry. All parameters were measured just before employment and after 172 k 21.3 days of work. Genetic deficiency of erythrocyte G6PD was observed in 5/40 subjects. Among G6PD normal subjects, increases in enzyme activity followed any change (increase or decrease) in blood lead. At the pre-employment test, serum cholesterol parameters did not show any correlation with G6PD activity or blood lead, and they were not affected by exposure. Cholesterol values observed among all the GBPD-deficient subjects were within the range of the rest of the study population.