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Effects of selective ultraviolet phototherapy (SUP) and local PUVA treatment on DNA synthesis in guinea pig skin

✍ Scribed by Helmut Pullmann; Attila Galosi; Christian Jakobeit; Gerd Klaus Steigleder


Publisher
Springer-Verlag
Year
1980
Tongue
English
Weight
474 KB
Volume
267
Category
Article
ISSN
0340-3696

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✦ Synopsis


The treatment with UV-light with wavelengths between 292.5-335 nm (known as selective UV-phototherapy, or SUP) and 320-390 nm (plus local treatment with8-methoxypsoralen, known as PUVA~x ) gave rise to a biphasic reaction of epidermal cell proliferation in guinea pig skin. A decrease of proliferative activity was followed by a synchronized stimulation of DNA synthesizing cells after 2-4 h. These quantitative displacements were accompanied by qualitative changes in the proliferative behaviour of epidermal cells in the S-compartment.