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Effects of selective phosphodiesterase Inhibitors on rat aorta and human platelets: smooth muscle tone, platelet aggregation and cAMP levels

โœ Scribed by K.-E. Andersson; S. Lindgren; T. Andersson; L. Vinge


Book ID
115884456
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
133 KB
Volume
183
Category
Article
ISSN
0014-2999

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The pharmacokinetics and pharmacologic effects of a potent, selective inhibitor of thromboxane synthetase, CV-4151 [(E)-7-phenyl-7-(3-pyridyl)-6-heptenoic acid] on prostanoid formation and platelet aggregation were studied in 42 healthy male volunteers. The drug was well tolerated. After oral admini