Effects of selected drugs on an auditory or thalamic conditioned stimulus eliciting recruitment in the cat
✍ Scribed by B. Dubinsky; W. J. Kinnard Jr.; J. P. Buckley
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 579 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
0 Minimally effective oral doses of chlorpromazine, imipramine, and pentobarbital necessary to block a discrete trial (bar-press) conditioned avoidance response were compared in cats chronically implanted with electrodes over the cerebral cortex and in the nucleus centralis medialis of the thalamus. Three conditioned stimulus contingencies consisting of tone and low or high voltage thalamic stimulation were presented. Minimal conditioned response blocking doses of these agents produced only slight qualitative changes in cortically recorded recruitment. Drug treatment affected the conditioned stimulus contingencies differentially, and the rank order in terms of ease of disruption of the conditioned avoidance response was high voltage thalamic conditioned stimulus > low voltage thalamic conditioned stimulus > auditory conditioned stimulus. The differential effect of these drugs might have been due to the additive inhibition of these agents and the thalamic conditioned stimulus on performance. With the exception of chlorpromazine, the behavioral effects of these drugs and their effects on recruitment were dissociated.
Keyphrases 0 Chlorpromazine-effects on conditioned avoidance response, conscious cat Lmipramine-effects on conditioned avoidance response, conscious cat 0 Pentobarbital-effects on conditioned avoidance response, conscious cat 0 Thalamic recruitment-effects of chlorpromazine, imipramine, and pentobarbital, conditioned avoidance response, conscious cat 1 Grass model 5-4 stimulator and SIU-4 isolation unit were used.