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Effects of Schisandrin B and α-tocopherol on lipid peroxidation,in vitroandin vivo

✍ Scribed by Duncan H. F. Mak; Siu-Po Ip; Pui-Chun Li; Michel K. T. Poon; Kam-Ming Ko

Publisher
Springer
Year
1996
Tongue
English
Weight
374 KB
Volume
165
Category
Article
ISSN
0300-8177

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✦ Synopsis

Effects of Schisandrin B (Sch B) and alpha-tocopherol (alpha-TOC) on ferric chloride (Fe3+) induced oxidation of erythrocyte membrane lipids in vitro and carbon tetrachloride (CCl4) induced lipid peroxidation in vivo were examined. While alpha-TOC could produce prooxidant and antioxidant effect on Fe(3+)-induced lipid peroxidation, Sch B only inhibited the peroxidation reaction. Pretreatment with alpha-TOC (3 mmol/kg/day x 3) did not protect against CCl4-induced lipid peroxidation and hepatocellular damage in mice, whereas Sch B pretreatment (0.3 mmol/3.0 mmol/kg/day x 3) produced a dose-dependent protective effect on the CCl4-induced hepatotoxicity. The ensemble of results suggests that the ability of Sch B to inhibit lipid peroxidation, while in the absence of pro-oxidant activity, may at least in part contribute to its hepatoprotective action.

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